منابع مشابه
Neuroproteomics - the tasks lying ahead.
The brain is unquestionably the most fascinating organ. Despite tremendous progress, current knowledge falls short of being able to explain its function. An emerging approach toward improved understanding of the molecular mechanisms underlying brain function is neuroproteomics. Today's neuroscientists have access to a battery of versatile technologies both in transcriptomics and proteomics. The...
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Bioinformatics is an emerging field of science emphasizing the application of mathematics, statistics, and informatics to study and analysis of very large molecular biological (mostly, genetic and genomic) systems (data sets). In a comparatively broader setup of large biological systems without necessarily having a predominant genetic undercurrent, and having genesis in biometry to biostatistic...
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An emerging way to study neuropsychiatric or neurodegenerative diseases is by performing proteomic analyses of brain tissues. Here, we describe methods used to isolate and identify the proteins associated with a sample of interest, such as the synapse, as well as to compare the levels of proteins in the sample under different conditions. These techniques, involving subcellular fractionation and...
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Proteomic analyses of brain tissues are becoming an integral component of neuroscientific research. In particular, the essential role of the synapse in neurotransmission and plasticity has brought about extensive efforts to identify its protein constituents. Recent studies have used a combination of subcellular fractionation and proteomic techniques to identify proteins associated with differen...
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Humanity has almost won its battle with many infectious diseases, thus increasing longevity, but is now confronted with challenges arising from population aging (1). A blessing turned into a curse as modern societies began struggling with prosperity diseases proliferation (2). Such obstacles are notable in the largest Western Balkan country (1). One-fifth of the Serbian population is aged 65, w...
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ژورنال
عنوان ژورنال: ELECTROPHORESIS
سال: 2006
ISSN: 0173-0835,1522-2683
DOI: 10.1002/elps.200500892